Indocarbazostatins C and D, new inhibitors of NGF-induced neuronal differentiation in PC12 cells.
نویسندگان
چکیده
Indocarbazostatins C (3) and D (4), new inhibitors of NGF-induced neurite outgrowth were isolated from culture broth of a mutant strain, Streptomyces sp. MUV-6-83. The structural elucidation of 3 and 4 revealed that these inhibitors were methyl ester analogs of the corresponding ethyl ester compounds, indocarbazostatin (1) and indocarbazostatin B (2), respectively.
منابع مشابه
Indocarbazostatin and indocarbazostatin B, novel inhibitors of NGF-induced neuronal differentiation in PC12 cells. I. Screening, taxonomy, fermentation and biological activities.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 57 10 شماره
صفحات -
تاریخ انتشار 2004