Indocarbazostatins C and D, new inhibitors of NGF-induced neuronal differentiation in PC12 cells.

نویسندگان

  • Yufei Feng
  • Nobuyasu Matsuura
  • Makoto Ubukata
چکیده

Indocarbazostatins C (3) and D (4), new inhibitors of NGF-induced neurite outgrowth were isolated from culture broth of a mutant strain, Streptomyces sp. MUV-6-83. The structural elucidation of 3 and 4 revealed that these inhibitors were methyl ester analogs of the corresponding ethyl ester compounds, indocarbazostatin (1) and indocarbazostatin B (2), respectively.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 57 10  شماره 

صفحات  -

تاریخ انتشار 2004